What are polynucleotides?

Polynucleotides are natural DNA fractions in a long chain that have antioxidant action and stimulate fibroblasts, resulting in increased collagen, a thicker, healthier epidermis and reduced inflammation.  

The polynucleotides used in cosmetic medicine to remodel the skin are made up of highly purified fragments of DNA extracted from wild salmon or trout sperm. The trout used are the same as used for food. Salmon and trout sperm DNA closely resembles human DNA. 

What can polynucleotides treat?

• Dull skin 
• Course skin 
• Wrinkles 
• Uneven Pigmentation 
• Redness 
• Dark circles 
• Acne scarring 
• Stretch marks 
• Surgical scarring 
• Hair loss 
• Not just for the face; hands, neck, chest, arms, knees. Any skin, anywhere on the body. 

How do polynucleotides work?

The use of polynucleotides in regenerative medicine is well established in tissue repair, following traumatic injury or surgery. Polynucleotides stimulate a receptor on cells which positively influences the following 

• Cell proliferation 
• The repair and regenerative actions of fibroblast cells 
• The production of collagen and elastin 
• The production of hyaluronic acid 
• The production of healthy new micro-blood vessels 
• The function of melanocytes which produce pigment. 
• They reduce inflammation 
• Regulate water balance 
• Regulate the formation of fat cells 
• Regenerate hair follicles 

What does treatment involve? 

The polynucleotides are distilled into a range of strengths and suspended in water for injection. They are injected into the superficial layer of the skin. The clinician uses either a fine needle or a cannula to administer multiple micro-doses into the target area. A course of three or four treatments 3 weeks apart is recommended to achieve optimum results. 

What results can I expect? 

The results are not instant but improvement can be noted from about three weeks and continues to improve over a twelve week period. Patients report a general improvement in the radiance of the skin, the skin should feel smoother and better hydrated. Pores and uneven colouration and texture can be improved. Fine lines and wrinkles are improved. Scarring can be improved, with less depth, smaller and better colour. When hair loss is the concern being addressed, new hair growth can be noted and existing hair will be healthier. Results will vary between individuals as the outcome is dependent upon the biological response of the individual and also lifestyle factors. 

How long do results last? 

Longevity does vary between individuals. Polynucleotides do not arrest the ageing process, therefore a maintenance treatment is recommended every six months. Life-style factors can effect longevity. If you choose not to maintain the results with further treatment, your skin will return to its pre-treatment state over time. 

Are polynucleotides safe?

The polynucleotides are highly purified and then sterilised from a licensed source, the production is regulated and the manufacture meets required CE standards of safety. All the protein molecules are removed, so there is no risk of allergy. The science is evidenced based and there are multiple published scientific papers demonstrating safety and efficacy in medicine for the treatment of tissue injury and also in aesthetic medicine. There are no known risks associated with the injection of exogenous (Non-self) polynucleotides. 

Possible side effects

Bruising and swelling can occur and may take time to settle, so it is not advisable to have treatment just before an important event. 

For 12-24 hours you may have visible bumps in the skin. Pin prick marks/scabs may take 5 days to resolve. 

Bruising can take up to 2 weeks to resolve. 

What are alternative treatments to polynucleotides?

Other treatments with a similar regenerative approach to skin results include: 

–HArmony-CA

– Skin boosters

–Micro-needling

What to expect

1. At consultation, we will discuss your main skin concerns and the treatment options available, including common side effects and possible complications. We will take a detailed medical history and assess suitability for this treatment.

    

   • Treatment

   At treatment, a topical anaesthetic cream can be used to numb the skin. The clinician uses either a fine needle or a cannula to administer multiple micro-doses into the target area. 

    

   • Review and follow on treatments

   A review at 3 weeks to assess results. A course of three or four treatments 3 weeks apart is recommended to achieve optimum resultsConsultation

Aftercare advice

You will need 12-24 hours of down-time after injectable skin boosters. Tiny bumps will appear under the skin across the treated area. These may be present for up to 24 hours until it spreads evenly across the face

In this first 24 hours it is crucial that you drink plenty of water to maximise the hydrating effects.